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E3 ligase Ligand-Linker Conjugates 18

" in MedChemExpress (MCE) Product Catalog:

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103615
    Thalidomide-O-amido-C4-N3
    1 Publications Verification

    Cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18

    		 E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Others
    Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Thalidomide-O-amido-C4-N3
  • HY-162191
    E3 Ligase Ligand-linker Conjugate 18

    		Ligands for E3 Ligase Autophagy Cancer
    E3 Ligase Ligand-linker Conjugate 18 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 18 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
    <em>E3</em> <em>Ligase</em> <em>Ligand-linker</em> <em>Conjugate 18</em>

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